Engineering

Nanotechnology

Enzyme

Biochemical engineering

Chemistry

Materials science

Immunology

Leukemia

Asparaginase

Lymphoblastic Leukemia

Immobilized enzyme

Biochemistry

Medicine

Bioconjugate Chemistry

There are two major applications of l-asparaginase (L-ASNase): leukemia therapy and the food industry. Especially, its chemotherapeutic effect has attracted interest from the scientific community and individual scientists. Therefore, to protect the intrinsic activity and half-time of L-ASNase, several carriers and immobilization techniques for immobilization of L-ASNase have been described in articles. Unfortunately, a comprehensive review about immobilization of L-ASNase has not been written until now. In this review, we have thoroughly discussed the carriers for L-ASNase by illustrating immobilization findings including both past and present applications. In addition, we have revealed advantages and disadvantages of immobilized enzyme and related it to free form. We believe that this review will not only provide background information, but also guide future developments.

Immobilization of<scp>l</scp>-Asparaginase on Carrier Materials: A Comprehensive Review

Immobilization ofl-Asparaginase on Carrier Materials: A Comprehensive Review