Protective Effects of Curcumin on Manganese-Induced BV-2 Microglial Cell Death

Curcumin, a bioactive component in tumeric, has been shown to exert antioxidant, anti-inflammatory, anticarcinogenic, hepatoprotective, and neuroprotective effects, but the effects of curcumin against manganese (Mn)-mediated neurotoxicity have not been studied. This study examined the protective effects of curcumin on Mn-induced cytotoxicity in BV-2 microglial cells. Curcumin (0.1–10 µM) dose-dependently prevented Mn (250 µM)-induced cell death....