Multiple outcomes and analyses in clinical trials create challenges for interpretation and research synthesis

ObjectiveTo identify variations in outcomes and results across reports of randomized clinical trials (RCTs).Study Design and SettingEligible RCTs examined gabapentin for neuropathic pain and quetiapine for bipolar depression, reported in public (e.g., journal articles) and nonpublic (e.g., clinical study reports) sources by 2015. We prespecified outcome domains. From each source, we collected “outcomes” (i.e., domain, measure, metric, method of...