Comparison of the diagnostic accuracy of PET/MRI to PET/CT-acquired FDG brain exams for seizure focus detection: a prospective study.

Published on May 16, 2017in Pediatric Radiology2.505
· DOI :10.1007/S00247-017-3888-8
Michael J. Paldino12
Estimated H-index: 12
(Boston Children's Hospital),
Erica Yang1
Estimated H-index: 1
+ 6 AuthorsVictor Seghers9
Estimated H-index: 9
(Boston Children's Hospital)
Sources
Abstract
Background There is great interest in positron emission tomography (PET)/magnetic resonance (MR) as a clinical tool due to its capacity to provide diverse diagnostic information in a single exam.
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20160.64Radiologe
2 Authors (J Grueneisen, L Umutlu)
References33
Newest
Hybrid PET/MRI systematically offers a complementary combination of two modalities that has often proven itself superior to the single modality approach in the diagnostic work-up of many neurological and psychiatric diseases. Emerging PET tracers, technical advances in multiparametric MRI and obvious workflow advantages may lead to a significant improvement in the diagnosis of dementia disorders, neurooncological diseases, epilepsy and neurovascular diseases using PET/MRI. Moreover, simultaneous...
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#2Sergios GatidisH-Index: 26
Last. Nina F. SchwenzerH-Index: 36
view all 11 authors...
Our initial results suggest that PET/MR imaging is a promising imaging modality for pediatric oncology; it has intrinsically low radiation exposure and should be considered for pediatric patients wherever available.
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imaging, respectively. Results from histopathology were used as the standard of reference. The mean and maximum standardized uptake value (SUVmean and SUVmax, respectively) and maximum diameter of the primary tumor was measured and compared in 18 F-FDG PET/CT and PET/MR imaging. Results: PET/MR imaging and 18F-FDG PET/CT agreed on T stages in 16 of 16 of patients (100%). All patients were correctly staged by 18F-FDG PET/CT and PET/MR (100%), compared with histopathology. There was no statistical...
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#1Arthur Varoquaux (Geneva College)H-Index: 21
#2Olivier Rager (Geneva College)H-Index: 16
Last. Minerva Becker (Geneva College)H-Index: 42
view all 10 authors...
Purpose Our objectives were to assess the quality of PET images and coregistered anatomic images obtained with PET/MR, to evaluate the detection of focal uptake and SUV, and to compare these findings with those of PET/CT in patients with head and neck tumours.
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#1Matthias Eiber (TUM: Technische Universität München)H-Index: 58
#2Toshiki Takei (TUM: Technische Universität München)H-Index: 3
Last. Ambros J. Beer (TUM: Technische Universität München)H-Index: 50
view all 11 authors...
Because of its higher soft-tissue contrast, whole-body integrated PET/MR offers potential advantages over PET/CT for evaluation of bone lesions. However, unlike PET/CT, PET/MR ignores the contribution of cortical bone in the attenuation map. Thus, the aims of this study were to evaluate the diagnostic performance of whole-body integrated (18)F-FDG PET/MR specifically for bone lesions and to analyze differences in standardized uptake value (SUV) quantification between PET/MR and PET/CT.One hundre...
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#1Flemming L. Andersen (Copenhagen University Hospital)H-Index: 25
#2Claes Nøhr Ladefoged (Copenhagen University Hospital)H-Index: 14
Last. Søren Holm (Copenhagen University Hospital)H-Index: 63
view all 9 authors...
Abstract Aim Combined PET/MR systems have now become available for clinical use. Given the lack of integrated standard transmission (TX) sources in these systems, attenuation and scatter correction (AC) must be performed using the available MR-images. Since bone tissue cannot easily be accounted for during MR-AC, PET quantification can be biased, in particular, in the vicinity of the skull. Here, we assess PET quantification in PET/MR imaging of patients using phantoms and patient data. Material...
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#1Ilja Bezrukov (MPG: Max Planck Society)H-Index: 17
#2Holger Schmidt (Siemens)H-Index: 31
Last. Bernd J. Pichler (Siemens)H-Index: 64
view all 7 authors...
Hybrid PET/MR systems have recently entered clinical practice. Thus, the accuracy of MR-based attenuation correction in simultaneously acquired data can now be investigated. We assessed the accuracy of 4 methods of MR-based attenuation correction in lesions within soft tissue, bone, and MR susceptibility artifacts: 2 segmentation-based methods (SEG1, provided by the manufacturer, and SEG2, a method with atlas-based susceptibility artifact correction); an atlas- and pattern recognition–based meth...
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#1Georg Schramm (HZDR: Helmholtz-Zentrum Dresden-Rossendorf)H-Index: 18
#2Jens Langner (HZDR: Helmholtz-Zentrum Dresden-Rossendorf)H-Index: 10
Last. Joerg van den Hoff (HZDR: Helmholtz-Zentrum Dresden-Rossendorf)H-Index: 12
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Objective Evaluation of the quantitative accuracy of MR-based attenuation correction (MRAC) in the Philips Ingenuity TF whole-body PET/MR.
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#1Anne Larsson (Umeå University)H-Index: 24
#2Adam Johansson (Umeå University)H-Index: 12
Last. Mikael Karlsson (Umeå University)H-Index: 27
view all 7 authors...
Object The aim of this study was to evaluate MR-based attenuation correction of PET emission data of the head, based on a previously described technique that calculates substitute CT (sCT) images from a set of MR images.
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#1Ilja Bezrukov (MPG: Max Planck Society)H-Index: 17
#2Frederic Mantlik (MPG: Max Planck Society)H-Index: 8
Last. Bernd J. Pichler (Siemens)H-Index: 64
view all 5 authors...
Recent progress has allowed hybrid positron emission tomography/magnetic resonance (PET/MR) systems to make the transition from research prototypes to systems with full potential for clinical imaging. Options for directly measuring the attenuation maps, as is possible with PET/computed tomography or PET transmission scans, are not included in PET/MR scanners. New methods to compute attenuation maps from MR data have therefore been developed.
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Cited By17
Newest
#1Yume Matsushita (Rits: Ritsumeikan University)
#2Dinh Tuan Tran (Rits: Ritsumeikan University)H-Index: 4
Last. Joo-Ho Lee (Rits: Ritsumeikan University)H-Index: 17
view all 4 authors...
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PET/MR imaging is in routine clinical use and is at least as effective as PET/CT for oncologic and neurologic studies with advantages with certain PET radiopharmaceuticals and applications. In addition, whole body PET/MR imaging substantially reduces radiation dosages compared with PET/CT which is particularly relevant to pediatric and young adult population. For cancer imaging, assessment of hepatic, pelvic, and soft-tissue malignancies may benefit from PET/MR imaging. For neurologic imaging, v...
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#1Akshay S. Chaudhari (Stanford University)H-Index: 14
#2Erik Mittra (OHSU: Oregon Health & Science University)H-Index: 6
Last. Greg Zaharchuk (Stanford University)H-Index: 64
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More widespread use of positron emission tomography (PET) imaging is limited by its high cost and radiation dose. Reductions in PET scan time or radiotracer dosage typically degrade diagnostic image quality (DIQ). Deep-learning-based reconstruction may improve DIQ, but such methods have not been clinically evaluated in a realistic multicenter, multivendor environment. In this study, we evaluated the performance and generalizability of a deep-learning-based image-quality enhancement algorithm app...
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#1Nicole Lorking (Aberd.: University of Aberdeen)H-Index: 1
#2Alison D. Murray (Aberd.: University of Aberdeen)H-Index: 49
Last. John T. O'Brien (University of Cambridge)H-Index: 140
view all 3 authors...
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To examine the utility of FDG-PET/MRI in patients with epilepsy by comparing the diagnostic accuracy of PET/MRI and PET/CT in epileptogenic zone (EZ) detection. This prospective study included 31 patients (17 males, 14 females) who underwent surgical resection for EZ. All patients were first scanned using FDG-PET/CT followed immediately with FDG-PET/MRI. Two series of PET plus standalone MR images were interpreted independently by five board-certified radiologists. A 4-point visual score was use...
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#1Stefan E. Poirier (UWO: University of Western Ontario)H-Index: 2
#2Benjamin Y. M. Kwan (Queen's University)H-Index: 2
Last. Jonathan D. Thiessen (UWO: University of Western Ontario)H-Index: 15
view all 13 authors...
OBJECTIVE Hybrid PET/MRI may improve detection of seizure-onset zone (SOZ) in drug-resistant epilepsy (DRE), however, concerns over PET bias from MRI-based attenuation correction (MRAC) have limited clinical adoption of PET/MRI. This study evaluated the diagnostic equivalency and potential clinical value of PET/MRI against PET/CT in DRE. MATERIALS AND METHODS MRI, FDG-PET and CT images (n = 18) were acquired using a hybrid PET/MRI and a CT scanner. To assess diagnostic equivalency, PET was recon...
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#1Gunes SagerH-Index: 2
#2Elife AkgunH-Index: 3
Last. Sait Sager (Istanbul University)H-Index: 10
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Abstract Background Standardized uptake values (SUVs) are important indexes for evaluating the accuracy of disease diagnoses achieved via fluoro-18 deoxyglucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) and positron emission tomography/magnetic resonance imaging (PET/MRI). The purpose of this study is to describe normal cerebral FDG uptake in the pediatric population and compare SUVmax/mean results for brain images obtained from PET/CT and PET/MRI in neurologically hea...
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#1Xiaonan Li (Capital Medical University)H-Index: 3
#2Tao Yu (Capital Medical University)H-Index: 11
Last. Xianchang Zhang (Siemens)
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Accurate localization of the epileptogenic zone (EZ) is a key factor to obtain good surgical outcome for refractory epilepsy patients. However, no technique, so far, can precisely locate the EZ, and there are barely any reports on the combined application of multiple technologies to improve the localization accuracy of the EZ. In this study, we aimed to explore the use of a multimodal method combining PET-MRI, fluid and white matter suppression (FLAWS)-a novel MRI sequence, and high-frequency os...
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#1Miao Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Wei Liu (SJTU: Shanghai Jiao Tong University)H-Index: 121
Last. Biao Li (SJTU: Shanghai Jiao Tong University)H-Index: 13
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Abstract Purpose Stereo-electroencephalography (SEEG) implantation before epilepsy surgery is critical for precise localization and complete resection of the seizure onset zone (SOZ). Combined metabolic and morphological imaging using hybrid PET/MRI may provide supportive information for the optimization of the SEEG coverage of brain structures. In this study, we originally imported PET/MRI images into the SEEG positioning system to evaluate the application of PET/MRI in guiding SEEG implantatio...
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#1Sandra Saade-Lemus (Children's Hospital of Philadelphia)H-Index: 4
#2Sara Reis Teixeira (Children's Hospital of Philadelphia)H-Index: 12
Last. Lisa J. States (Children's Hospital of Philadelphia)H-Index: 17
view all 5 authors...
Add "improving" before "detection"? PET/MR is beneficial particularly in pediatric patients who undergo recurrent imaging, such as those with cancer or chronic inflammatory disease. PET/MR has advantages compared with PET/computed tomography, including decreased radiation exposure and superior characterization of soft tissue. Ongoing challenges include reducing examination duration and costs and detection of pulmonary lesions. Accepted clinical applications of PET/MR in pediatric patients are ev...
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