Pro-inflammatory Ca ++ -activated K + channels are inhibited by hydroxychloroquine.
Abstract
Antimalarials have demonstrated beneficial effects in Systemic Lupus Erithematosus and Rheumatoid Arthritis. However, the mechanisms and the molecular players targeted by these drugs remain obscure. Although hydroxychloroquine (HCQ) is a known ion channel inhibitor, this property has not been linked to its anti-inflammatory effects. We aimed to study whether HCQ inhibits pro-inflammatory ion channels. Electrophysiology experiments demonstrated...
Paper Details
Title
Pro-inflammatory Ca ++ -activated K + channels are inhibited by hydroxychloroquine.
Published Date
May 15, 2017
Journal
Volume
7
Issue
1
Pages
1892 - 1892
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History