Development and Validation of the PREMM5 Model for Comprehensive Risk Assessment of Lynch Syndrome
Abstract
Purpose Current Lynch syndrome (LS) prediction models quantify the risk to an individual of carrying a pathogenic germline mutation in three mismatch repair (MMR) genes: MLH1, MSH2, and MSH6. We developed a new prediction model, PREMM 5 , that incorporates the genes PMS2 and EPCAM to provide comprehensive LS risk assessment. Patients and Methods PREMM 5 was developed to predict the likelihood of a mutation in any of the LS genes by using...
Paper Details
Title
Development and Validation of the PREMM5 Model for Comprehensive Risk Assessment of Lynch Syndrome
Published Date
Jul 1, 2017
Journal
Volume
35
Issue
19
Pages
2165 - 2172
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