Rational design of nanoparticles towards targeting antigen-presenting cells and improved T cell priming
Abstract
Vaccination is a promising strategy to trigger and boost immune responses against cancer or infectious disease. We have designed, synthesized and characterized aliphatic-polyester (poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NP) to investigate how the nature of protein association (adsorbed versus entrapped) and polymer/surfactant concentrations impact on the generation and modulation of antigen-specific immune responses. The ability of...
Paper Details
Title
Rational design of nanoparticles towards targeting antigen-presenting cells and improved T cell priming
Published Date
Jul 1, 2017
Volume
258
Pages
182 - 195
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