Structures of closed and open conformations of dimeric human ATM
Abstract
ATM (ataxia-telangiectasia mutated) is a phosphatidylinositol 3-kinase–related protein kinase (PIKK) best known for its role in DNA damage response. ATM also functions in oxidative stress response, insulin signaling, and neurogenesis. Our electron cryomicroscopy (cryo-EM) suggests that human ATM is in a dynamic equilibrium between closed and open dimers. In the closed state, the PIKK regulatory domain blocks the peptide substrate–binding site,...
Paper Details
Title
Structures of closed and open conformations of dimeric human ATM
Published Date
May 1, 2017
Journal
Volume
3
Issue
5
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