Silicosis, then microscopic polyangiitis—antineutrophil cytoplasmic antibodies‐associated vasculitis may be work‐related disease in patients with silicosis

Published on May 2, 2017in Journal of General and Family Medicine
· DOI :10.1002/JGF2.77
Yoshito Nishimura5
Estimated H-index: 5
Tomohiro Tsuda2
Estimated H-index: 2
+ 4 AuthorsToshihiko Nagao1
Estimated H-index: 1
: A 74-year-old man with silicosis was admitted to the hospital because of prolonged fever. After referral to internal medicine for persistent fever and renal dysfunction, workup revealed antineutrophil cytoplasmic antibodies (ANCA) positivity. He was diagnosed with microscopic polyangiitis (MPA). After treatment with immunosuppressive therapy, his condition improved. Herein, we discuss silica exposure and the risk of ANCA-associated vasculitis (AAV), particularly in terms of work-related diseases. Silica exposure is a notorious risk factor for developing AAV, which is potentially lethal when not identified. When we see a silicosis patient with new-onset prolonged fever and generalized fatigue, AAV should be taken into consideration. This case report provides beneficial information to reliably assess patients at high risk of developing AAV in primary care settings.
#1Antonio Greco (Sapienza University of Rome)H-Index: 29
#2Armando De Virgilio (Sapienza University of Rome)H-Index: 26
Last. Marco de Vincentiis (Sapienza University of Rome)H-Index: 25
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Abstract Microscopic polyangiitis (MPA) is an idiopathic autoimmune disease characterized by systemic vasculitis. The disease predominantly affects small-calibre blood vessels and is associated with the presence of antineutrophil cytoplasmic autoantibodies (ANCA). Microscopic polyangiitis was considered to be a disease entity by Savage et al. in 1985. Microscopic polyangiitis has a reported low incidence and a slight male predominance. The aetiology of MPA remains unknown. There is, however, inc...
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#1Suni Lee (Kawasaki Medical School)H-Index: 6
#2Hidenori Matsuzaki (Kawasaki Medical School)H-Index: 24
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Silica particles and asbestos fibers, which are known as typical causatives of pneumoconiosis, induce lung fibrosis. Moreover, silicosis patients often complicate with autoimmune diseases, and asbestos-exposed patients suffer from malignant diseases such as pleural mesothelioma and lung cancer. We have been conducting experimental studies to investigate altered regulation of self-tolerance caused by silica exposure, including analyses using specimens such as plasma and immunocompetent cells obta...
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#1Kei EbisawaH-Index: 2
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#1Richard A. Watts (UEA: University of East Anglia)H-Index: 64
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#2Hiroaki Hayashi (Kawasaki Medical School)H-Index: 6
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Abstract Autoimmune disorders are induced by various environmental and occupational substances. Among the most typical factors involving these substances, it is well known that silica exposure causes not only pulmonary fibrosis known as silicosis, but also induces autoimmune diseases such as rheumatoid arthritis known as Caplan's syndrome, systemic sclerosis, systemic lupus erythematosus, and anti-neutrophil cytoplasmic autoantibody (ANCA)-related vasculitis/nephritis. To investigate the immunol...
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#1Min Chen (UMCG: University Medical Center Groningen)H-Index: 30
#1Min Chen (UMCG: University Medical Center Groningen)H-Index: 4
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Anti-neutrophil cytoplasmic antibodies, directed against constituents of granules of neutrophils and lysosomes of monocytes, are serological markers of small vessel vasculitides, including Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and renal-limited vasculitis. These vasculitides are collectively termed ANCA-associated vasculitides (AAV). Environmental factors have been considered important in the development of ANCA, including silica, infection especially with St...
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#1Susan L. Hogan (UNC: University of North Carolina at Chapel Hill)H-Index: 60
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#1Jiřina Bartůňková (Charles University in Prague)H-Index: 18
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Cited By4
#1Cunxiang Bo (Academy of Medical Sciences, United Kingdom)H-Index: 8
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Silicosis is a systemic disease characterized by chronic persistent inflammation and incurable pulmonary fibrosis with the underlying molecular mechanisms to be fully elucidated. In this study, we employed tandem mass tag (TMT) based on quantitative proteomics technology to detect differentially expressed proteins (DEPs) in lung tissues of silica-exposed rats. A total of 285 DEPs (145 upregulated and 140 downregulated) were identified. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genom...
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#1N Rao (St. Vincent's Health System)
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