High non-esterified fatty acid concentrations promote expression and secretion of fibroblast growth factor 21 in calf hepatocytes cultured in vitro

Summary Negative energy balance is considered as the pathological basis of energy metabolic disorders in periparturient dairy cows. Serum non‐esterified fatty acids ( NEFA ) are one of the most important indicators of energy balance status. Fibroblast growth factor 21 ( FGF 21) has been identified as a hepatokine involved in regulation of metabolic adaptations, such as promoting hepatic lipid oxidation and ketogenesis, during energy deprivation....