Altered Functional Connectivity of Striatal Subregions in Patients with Multiple Sclerosis

Abnormal corticostriatal resting-state functional connectivity (rsFC) has been implicated in the neuropathology of multiple sclerosis (MS). As a component of the basal ganglia, the striatum is involved in diverse functions including movement, cognition, emotion and limbic information processing. However, the brain circuits of the striatal subregions contributing to the changes in rsFC in RRMS patients remain unknown. As individual striatal...