Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates
Abstract
As the antibody drug conjugate (ADC) community continues to shift towards site-specific conjugation technology, there is a growing need to understand how the site of conjugation impacts the biophysical and biological properties of an ADC. In order to address this need, we prepared a carefully selected series of engineered cysteine ADCs and proceeded to systematically evaluate their potency, stability, and PK exposure. The site of conjugation did...
Paper Details
Title
Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates
Published Date
Apr 24, 2017
Journal
Volume
19
Issue
4
Pages
1123 - 1135
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