Prion-like Spreading in Tauopathies
Abstract
Tau is a microtubule-associated protein that functions in regulating cytoskeleton dynamics, especially in neurons. Misfolded and aggregated forms of tau produce pathological structures in a number of neurodegenerative diseases, including Alzheimer's disease (AD) and tauopathy dementias. These disorders can present with a sporadic etiology, such as in AD, or a familial etiology, such as in some cases of frontotemporal dementia with parkinsonism....
Paper Details
Title
Prion-like Spreading in Tauopathies
Published Date
Feb 1, 2018
Journal
Volume
83
Issue
4
Pages
337 - 346
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Notes
History