Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradation
Abstract
Chaperone-mediated autophagy (CMA), a selective form of protein lysosomal degradation, is maximally activated in stress situations to ensure maintenance of cellular homeostasis. CMA activity decreases with age and in several human chronic disorders, but in contrast, in most cancer cells, CMA is upregulated and required for tumor growth. However, the role of CMA in malignant transformation remains unknown. In this study, we demonstrate that CMA...
Paper Details
Title
Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradation
Published Date
Apr 14, 2017
Journal
Volume
13
Issue
5
Pages
928 - 940
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