The HSP90 chaperone machinery

Volume: 18, Issue: 6, Pages: 345 - 360
Published: Jun 1, 2017
Abstract
The heat shock protein 90 (HSP90) chaperone machinery is a key regulator of proteostasis under both physiological and stress conditions in eukaryotic cells. As HSP90 has several hundred protein substrates (or 'clients'), it is involved in many cellular processes beyond protein folding, which include DNA repair, development, the immune response and neurodegenerative disease. A large number of co-chaperones interact with HSP90 and regulate the...
Paper Details
Title
The HSP90 chaperone machinery
Published Date
Jun 1, 2017
Volume
18
Issue
6
Pages
345 - 360
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