Hypaphorine, an Indole Alkaloid Isolated fromCaragana korshinskiiKom., Inhibites 3T3-L1 Adipocyte Differentiation and Improves Insulin Sensitivityin Vitro

Obesity, a major health problem worldwide, is a complex multifactorial chronic disease that increases the risk for insulin resistance, type 2 diabetes, coronary heart disease, and hypertension. In this study, we assessed methods to isolate hypaphorine, a potent drug candidate for obesity and insulin resistance. Semi-preparative reversed-phase liquid chromatography (semi-preparative RPLC) was established as a method to separate three compounds,...