Glucocorticoids activate a synapse weakening pathway culminating in tau phosphorylation in the hippocampus
Abstract
Evidence suggests that the stress hormones glucocorticoids (GCs) can cause cognitive deficits and neurodegeneration. Previous studies have found GCs facilitate physiological synapse weakening, termed long-term depression (LTD), though the precise mechanisms underlying this are poorly understood. Here we show that GCs activate glycogen synthase kinase-3 (GSK-3), a kinase crucial to synapse weakening signals. Critically, this ultimately leads to...
Paper Details
Title
Glucocorticoids activate a synapse weakening pathway culminating in tau phosphorylation in the hippocampus
Published Date
Jul 1, 2017
Journal
Volume
121
Pages
42 - 51
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