Review paper

Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis

Volume: 133, Issue: 6, Pages: 863 - 885
Published: Apr 13, 2017
Abstract
In the fatal disease-amyotrophic lateral sclerosis (ALS)-upper (corticospinal) motor neurons (MNs) and lower somatic MNs, which innervate voluntary muscles, degenerate. Importantly, certain lower MN subgroups are relatively resistant to degeneration, even though pathogenic proteins are typically ubiquitously expressed. Ocular MNs (OMNs), including the oculomotor, trochlear and abducens nuclei (CNIII, IV and VI), which regulate eye movement,...
Paper Details
Title
Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis
Published Date
Apr 13, 2017
Volume
133
Issue
6
Pages
863 - 885
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