Schizophrenia (object-oriented programming)

Antipsychotic

Psychosis

Internal medicine

Clozapine

Medicine

Cohort

Psychiatry

Psychological Medicine

Background We examined longitudinally the course and predictors of treatment resistance in a large cohort of first-episode psychosis (FEP) patients from initiation of antipsychotic treatment. We hypothesized that antipsychotic treatment resistance is: ( a ) present at illness onset; and ( b ) differentially associated with clinical and demographic factors. Method The study sample comprised 323 FEP patients who were studied at first contact and at 10-year follow-up. We collated clinical information on severity of symptoms, antipsychotic medication and treatment adherence during the follow-up period to determine the presence, course and predictors of treatment resistance. Results From the 23% of the patients, who were treatment resistant, 84% were treatment resistant from illness onset. Multivariable regression analysis revealed that diagnosis of schizophrenia, negative symptoms, younger age at onset, and longer duration of untreated psychosis predicted treatment resistance from illness onset. Conclusions The s...

Antipsychotic treatment resistance in first-episode psychosis: prevalence, subtypes and predictors