Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.

Volume: 8, Issue: 1, Pages: 14740 - 14740
Published: Mar 27, 2017
Abstract
δ-secretase, also known as asparagine endopeptidase (AEP) or legumain, is a lysosomal cysteine protease that cleaves both amyloid precursor protein (APP) and tau, mediating the amyloid-β and tau pathology in Alzheimer’s disease (AD). Here we report the therapeutic effect of an orally bioactive and brain permeable δ-secretase inhibitor in mouse models of AD. We performed a high-throughput screen and identified a non-toxic and selective...
Paper Details
Title
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Published Date
Mar 27, 2017
Volume
8
Issue
1
Pages
14740 - 14740
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