Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions
Abstract
A number of human diseases, such as arthritis and atherosclerosis, include characteristic pathology in specific anatomical locations. Here we show transcriptomic differences in synovial fibroblasts from different joint locations and that HOX gene signatures reflect the joint-specific origins of mouse and human synovial fibroblasts and synovial tissues. Alongside DNA methylation and histone modifications, bromodomain and extra-terminal reader...
Paper Details
Title
Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions
Published Date
Mar 23, 2017
Journal
Volume
8
Issue
1
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