metal free

bond activation

iii catalyzed

given article information

secondary amines

carboxylic acids

reaction

ammonia borane

Accounts of chemical research

The development of efficient and elective transition metal catalyst systems enabling a direct C-H amination of hydrocarbons using ammonia is highly desirable considering the fact that ammonia is the most readily available nitrogen source. It is anticipated that a new mechanistic scaffold distinct from the currently applicable ones will guide this research eventually to have broad applicability in synthetic methodology, medicinal chemistry, and materials science.

The Use of Ammonia as an Ultimate Amino Source in the Transition Metal-Catalyzed C–H Amination