Enhanced Directional Migration of Cancer Stem Cells in 3D Aligned Collagen Matrices
Abstract
Directed cell migration by contact guidance in aligned collagenous extracellular matrix (ECM) is a critical enabler of breast cancer dissemination. The mechanisms of this process are poorly understood, particularly in 3D, in part because of the lack of efficient methods to generate aligned collagen matrices. To address this technological gap, we propose a simple method to align collagen gels using guided cellular compaction. Our method yields...
Paper Details
Title
Enhanced Directional Migration of Cancer Stem Cells in 3D Aligned Collagen Matrices
Published Date
Mar 14, 2017
Journal
Volume
112
Issue
5
Pages
1023 - 1036
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History