Wounds Difficult to Heal: An Effective Treatment Strategy

Published on Oct 31, 2017in Current Vascular Pharmacology2.672
· DOI :10.2174/1570161115666170301122216
Raffaele Capoano10
Estimated H-index: 10
Rita Businaro18
Estimated H-index: 18
(Sapienza University of Rome)
+ 9 AuthorsSerafino Ricci15
Estimated H-index: 15
OBJECTIVE: Treatment of wounds difficult to heal concerns 50% of the elderly population in Italy and is therefore an extreme relevance social burden. The present study shows how the treatment with autologous leuco-platelets reduces the healing time of wounds improving the functional recovery. PATIENTS AND METHODS: One hundred patients with ulcers of the legs were divided in two groups: 1) 50 patients treated with conventional therapies; 2) 50 patients treated with autologous leuco-platelet concentrate (LPC) and HYAFF as a scaffold. RESULTS: After 2 months a 49% reduction of the wound area was observed in the second group and in a remarkable share (about 65%) wound reduction was obtained in 15 days (4 LPC dressings). On the contrary, patients treated only by simple medications, showed a longer healing time and a greater percentage of failures. Morphometric analysis of bioptic samples obtained from the edge as well as from the bottom of the lesions obtained from the LPC group, detected an abundant presence of neoformed capillaries, characterized by a cubic, "reactive endothelium", close to the site of leuco-platelet infiltration. CONCLUSIONS: These results suggest that healing was promoted not only by limiting bacterial infections but also by the release of chemiotatic and proangiogenetic factors from leukocytes and platelets, improving the neoformation of capillaries.
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