Review paper

Polyplex Evolution: Understanding Biology, Optimizing Performance

Volume: 25, Issue: 7, Pages: 1476 - 1490
Published: Jul 1, 2017
Abstract
Polyethylenimine (PEI) is a gold standard polycationic transfectant. However, the highly efficient transfecting activity of PEI and many of its derivatives is accompanied by serious cytotoxic complications and safety concerns at innate immune levels, which impedes the development of therapeutic polycationic nucleic acid carriers in general and their clinical applications. In recent years, the dilemma between transfection efficacy and adverse PEI...
Paper Details
Title
Polyplex Evolution: Understanding Biology, Optimizing Performance
Published Date
Jul 1, 2017
Volume
25
Issue
7
Pages
1476 - 1490
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