Sertoli and Germ Cell Vascular Endothelial Growth Factor A (VEGFA) Loss Using pDMRT-1 Cre Affects Testis Size and Reduces Spermatogenesis Potentially Through Altering Genes Regulating the Spermatogonial Stem Cell Niche.

VEGFA has been demonstrated to be integral in testis morphology, both in vascular development and in cord formation. Recent data from our laboratory have also demonstrated a role for VEGFA isoforms in spermatogonial stem cell renewal and differentiation. Thus, our hypothesis was that VEGFA loss in Sertoli and germ cells would affect spermatogenesis by depleting the spermatogonial stem cell population. To test the hypothesis, we utilized a line...