The Migration of Platelets and their Interaction with Other Migrating Cells

Published on Jan 1, 2017
· DOI :10.1007/978-3-319-47462-5_25
Eleonora Petito7
Estimated H-index: 7
(University of Perugia),
Stefania Momi29
Estimated H-index: 29
(University of Perugia),
Paolo Gresele69
Estimated H-index: 69
(University of Perugia)
Sources
Abstract
Platelets, beyond their well-described role in haemostasis and thrombosis, act as inflammatory cells playing an active role in several inflammatory conditions. As observed with other inflammatory cells platelets can migrate in vitro, either randomly or in the direction of a chemotactic agent, and in vivo, into inflammed tissues in response to different stimuli. In this chapter we will summarize the current knowledge about the mechanisms that regulate platelet chemotaxis, the evidence for the ability of platelets to migrate in vitro and in vivo, and the mechanisms by which platelets influence chemotaxis of other cells.
📖 Papers frequently viewed together
1986
1 Author (B. M. Czarnetzki)
1 Citations
119 Citations
1981
2 Authors (R. Snyderman, M.C. Pike)
References143
Newest
#1Ingrid Slaba (U of C: University of Calgary)H-Index: 3
#2Paul Kubes (U of C: University of Calgary)H-Index: 116
Over the last several decades, a new paradigm of platelet function has evolved. Platelets, long forgotten hemostatic cells, were demonstrated to be versatile immune effector cells engaged in every compartment of the immune system. Platelets express multiple immune receptors, such as toll-like receptors, allowing them to sense both pathogen- and danger-associated signals. Upon activation, platelets release a large array of biologically active molecules, like cytokines, chemokines, and growth fact...
3 CitationsSource
#1Harry F. G. Heijnen (UU: Utrecht University)H-Index: 32
#2Suzanne J.A. Korporaal (UU: Utrecht University)H-Index: 18
Platelets are key players in hemostasis, the process that is essential in the prevention of blood loss in response to injury of a blood vessel. When platelets encounter breaches in the vascular wall, they rapidly adhere to the site of injury and aggregate to form a platelet plug. Subsequently coagulation will be initiated resulting in a fibrin network that reinforces the plug. Failure to form an adequate plug leads to a bleeding tendency. On the other hand, excessive platelet reactivity leads to...
6 CitationsSource
#1Stefania Momi (University of Perugia)H-Index: 29
#2Viroj WiwanitkitH-Index: 1
In biology, phylogenetics is the study of the evolutionary history and relationships among individuals or groups of organisms (e.g., species or populations). At present, molecular phylogenetics is the modern technique for helping with the classification of biological systems. This chapter briefly discusses the phylogeny of blood platelets.
4 CitationsSource
#1Augusto Carducci (Sapienza University of Rome)H-Index: 2
#2Gaia Scafetta (Sapienza University of Rome)H-Index: 8
Last. Elena De Falco (Sapienza University of Rome)H-Index: 20
view all 14 authors...
Tenon's fibroblasts (TFs), widely employed as in vitro model for many ophthalmological studies, are routinely cultured with FBS. Platelet Lysate (PL), a hemoderivate enriched with growth factors and cytokines has been largely tested in several clinical applications and as substitute of FBS in culture. Here, we investigate whether PL can exert biological effects on TF populations similarly to other cell types. Results show that PL significantly enhances cell proliferation and migration vs. FBS, w...
8 CitationsSource
#1Madhumita Chatterjee (University of Tübingen)H-Index: 23
#2S.N.I. von Ungern-Sternberg (University of Tübingen)H-Index: 1
Last. Meinrad Gawaz (University of Tübingen)H-Index: 88
view all 9 authors...
Platelets store and release CXCL12 (SDF-1), which governs differentiation of hematopoietic progenitors into either endothelial or macrophage-foam cells. CXCL12 ligates CXCR4 and CXCR7 and regulates monocyte/macrophage functions. This study deciphers the relative contribution of CXCR4–CXCR7 in mediating the effects of platelet-derived CXCL12 on monocyte function, survival, and differentiation. CXCL12 and macrophage migration inhibitory factor (MIF) that ligate CXCR4–CXCR7 induced a dynamic bidire...
75 CitationsSource
#1Benoit LaffontH-Index: 8
#2Aurélie CorduanH-Index: 6
Last. Patrick ProvostH-Index: 34
view all 7 authors...
Platelet microparticles (MPs) represent the most abundant MPs subtype in the circulation, and can mediate intercellular communication through delivery of bioactives molecules, such as cytokines, proteins, lipids and RNAs. Here, we show that platelet MPs can be internalised by primary human macrophages and deliver functional miR-126–3p. The increase in macrophage miR-126–3p levels was not prevented by actinomycin D, suggesting that it was not due to de novo gene transcription. Platelet MPs dose-d...
92 CitationsSource
#1Robert Goggs (Cornell University)H-Index: 21
#2Christopher Williams (UoB: University of Bristol)H-Index: 30
Last. Alastair W. Poole (UoB: University of Bristol)H-Index: 33
view all 4 authors...
Rho GTPases are critical for platelet function. Although the roles of RhoA, Rac and Cdc42 are characterized, platelets express other Rho GTPases, whose activities are less well understood. This review summarizes our understanding of the roles of platelet Rho GTPases and focuses particularly on the functions of Rif and RhoG. In human platelets, Rif interacts with cytoskeleton regulators including formins mDia1 and mDia3, whereas RhoG binds SNARE-complex proteins and cytoskeletal regulators ELMO a...
31 CitationsSource
#1Theresa H. Wirtz (RWTH Aachen University)H-Index: 5
#2Sabine Tillmann (RWTH Aachen University)H-Index: 5
Last. Jürgen Bernhagen (LMU: Ludwig Maximilian University of Munich)H-Index: 19
view all 9 authors...
Abstract Objective Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine with chemokine-like functions that plays a role in several inflammatory diseases including atherosclerosis. We recently demonstrated that in addition to macrophages and endothelial cells, platelets are a source of MIF. However, the functional relevance of platelet-derived MIF and differences to other platelet chemokines are unclear. Here, we sought to define the secretion pattern of platelet MIF and to ch...
25 CitationsSource
Objective— Atherosclerosis, an inflammatory disease of arterial vessel walls, requires migration and matrix metalloproteinase (MMP)-9–dependent invasion of monocytes/macrophages into the vascular wall. MMP-9 expression is stimulated by transcription factor nuclear factor-κB, which is regulated by inhibitor κB (IκB) and thus IκB kinase. Regulators of nuclear factor-κB include serum- and glucocorticoid-inducible kinase 1 (SGK1). The present study explored involvement of SGK1 in vascular inflammati...
37 CitationsSource
#1Richard T. Amison ('KCL': King's College London)H-Index: 9
#2Stefania Momi (University of Perugia)H-Index: 29
Last. Simon C. Pitchford ('KCL': King's College London)H-Index: 25
view all 8 authors...
Background Clinical studies reveal platelet activation in patients with asthma, allergic rhinitis, and eczema. This is distinct from platelet aggregation, which is critical for the maintenance of hemostasis and in which a role for platelet purinergic receptors is well documented. However, purines are also essential for inflammatory cell trafficking in animal models of allergic lung inflammation, which are known to be platelet dependent, yet the role of purines in the platelet activation accompan...
40 CitationsSource
Cited By5
Newest
#1Angela Sacco (University of Chieti-Pescara)H-Index: 7
#2Annalisa Bruno (University of Chieti-Pescara)H-Index: 1
Last. Paola PatrignaniH-Index: 60
view all 20 authors...
Inflammatory bowel disease (IBD) is associated with an increased risk for thromboembolism, platelet activation, and abnormalities in platelet number and size. In colitis, platelets can extravasate into the colonic interstitium. We generated a mouse with a specific deletion of cyclooxygenase (COX)-1 in megakaryocytes/platelets [(COX-1 conditional knockout (cKO)] to clarify the role of platelet activation in the development of inflammation and fibrosis in dextran sodium sulfate (DSS)–induced colit...
5 CitationsSource
#1Eleonora Petito (University of Perugia)H-Index: 7
#2Richard T. Amison ('KCL': King's College London)H-Index: 9
Last. Clive P. Page ('KCL': King's College London)H-Index: 86
view all 8 authors...
Abstract Introduction Platelets participate in inflammatory disorders through a variety of different functional responses, including chemotaxis, platelet-leukocyte complex formation and facilitation of leukocyte recruitment that are thought to be distinct from platelet aggregation. This may account for why classical anti-platelet drugs have failed to ameliorate inflammatory disorders where platelets are known to participate, suggesting that distinct pathways may control inflammatory and haemosta...
6 CitationsSource
#1Sajeel A. Shah ('KCL': King's College London)H-Index: 2
#2Clive P. Page ('KCL': King's College London)H-Index: 86
Last. Simon C. Pitchford ('KCL': King's College London)H-Index: 25
view all 3 authors...
The importance of platelet activation during haemostasis is well understood. An understanding of these mechanisms has led to the use of several classes of anti-platelet drugs to inhibit aggregation for the prevention of thrombi during cardiovascular disease. It is now also recognised that platelets can function very differently during inflammation, as part of their role in the innate immune response against pathogens. This dichotomy in platelet function occurs through distinct physiological proc...
20 CitationsSource
#1David G. Menter (University of Texas MD Anderson Cancer Center)H-Index: 46
#2Scott Kopetz (University of Texas MD Anderson Cancer Center)H-Index: 88
Last. Kenneth V. Honn (WSU: Wayne State University)H-Index: 81
view all 7 authors...
Platelets serve as “first responders” during normal wounding and homeostasis. Arising from bone marrow stem cell lineage megakaryocytes, anucleate platelets can influence inflammation and immune regulation. Biophysically, platelets are optimized due to size and discoid morphology to distribute near vessel walls, monitor vascular integrity, and initiate quick responses to vascular lesions. Adhesion receptors linked to a highly reactive filopodia-generating cytoskeleton maximizes their vascular su...
58 CitationsSource
#1Stefania Momi (University of Perugia)H-Index: 29
#2Simon C. Pitchford ('KCL': King's College London)H-Index: 25
Last. Clive P. Page ('KCL': King's College London)H-Index: 86
view all 4 authors...
The role of platelets as inflammatory cells is now well established. Given the peculiar characteristics of the lung circulation, with a broad capillary bed, platelets are especially involved with the physiology of the lungs and play a key role in a number of inflammatory lung disorders. The platelet precursors, megakaryocytes, are detected in the lung microcirculation; moreover platelets with their endothelium-protective and vascular reparative activities contribute to the lung capillary blood b...
3 CitationsSource