The Migration of Platelets and their Interaction with Other Migrating Cells

Published on Jan 1, 2017
· DOI :10.1007/978-3-319-47462-5_25
Eleonora Petito7
Estimated H-index: 7
(University of Perugia),
Stefania Momi29
Estimated H-index: 29
(University of Perugia),
Paolo Gresele69
Estimated H-index: 69
(University of Perugia)
Platelets, beyond their well-described role in haemostasis and thrombosis, act as inflammatory cells playing an active role in several inflammatory conditions. As observed with other inflammatory cells platelets can migrate in vitro, either randomly or in the direction of a chemotactic agent, and in vivo, into inflammed tissues in response to different stimuli. In this chapter we will summarize the current knowledge about the mechanisms that regulate platelet chemotaxis, the evidence for the ability of platelets to migrate in vitro and in vivo, and the mechanisms by which platelets influence chemotaxis of other cells.
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