Imaging ERK and PKA Activation in Single Dendritic Spines during Structural Plasticity
Abstract
Summary null Extracellular signal-regulated kinase (ERK) and protein kinase A (PKA) play important roles in LTP and spine structural plasticity. While fluorescence resonance energy transfer (FRET)-based sensors for these kinases had previously been developed, they did not provide sufficient sensitivity for imaging small neuronal compartments, such as single dendritic spines in brain slices. Here we improved the sensitivity of FRET-based kinase...
Paper Details
Title
Imaging ERK and PKA Activation in Single Dendritic Spines during Structural Plasticity
Published Date
Mar 22, 2017
Journal
Volume
93
Issue
6
Pages
1315 - 1324
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