Associations of CYP 2C9 and CYP 2A6 Polymorphisms with the Concentrations of Valproate and its Hepatotoxin Metabolites and Valproate‐Induced Hepatotoxicity
Volume: 121, Issue: 2, Pages: 138 - 143
Published: May 3, 2017
Abstract
The aim of this study was to compare genetic polymorphisms and concentrations of hepatotoxic metabolites in patients with epilepsy and liver injury and those with normal liver function receiving valproate monotherapy to identify risk factors for VPA ‐induced hepatotoxicity. A total of 279 Chinese patients with epilepsy were divided into an abnormal liver function ( ANLFT ) group (n = 79) and a normal liver function ( NLFT ) group (n = 200)....
Paper Details
Title
Associations of CYP 2C9 and CYP 2A6 Polymorphisms with the Concentrations of Valproate and its Hepatotoxin Metabolites and Valproate‐Induced Hepatotoxicity
Published Date
May 3, 2017
Volume
121
Issue
2
Pages
138 - 143
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