TGF-β Family Signaling in Tumor Suppression and Cancer Progression
Volume: 9, Issue: 12, Pages: a022277 - a022277
Published: Feb 28, 2017
Abstract
Transforming growth factor-β (TGF-β) induces a pleiotropic pathway that is modulated by the cellular context and its integration with other signaling pathways. In cancer, the pleiotropic reaction to TGF-β leads to a diverse and varied set of gene responses that range from cytostatic and apoptotic tumor-suppressive ones in early stage tumors, to proliferative, invasive, angiogenic, and oncogenic ones in advanced cancer. Here, we review the...
Paper Details
Title
TGF-β Family Signaling in Tumor Suppression and Cancer Progression
Published Date
Feb 28, 2017
Volume
9
Issue
12
Pages
a022277 - a022277
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