Piccolo mediates EGFR signaling and acts as a prognostic biomarker in esophageal squamous cell carcinoma

Volume: 36, Issue: 27, Pages: 3890 - 3902
Published: Mar 6, 2017
Abstract
The presynaptic cytomatrix protein Piccolo, encoded by PCLO, is frequently mutated and amplified in esophageal squamous cell carcinoma (ESCC), but its exact roles in ESCC remain unclear. Here we report that Piccolo expression correlates significantly with clinical stage, patient survival and tumor embolus. Functional studies demonstrate that PCLO knockdown remarkably attenuates ESCC malignancy in vitro and in vivo, and ectopic EGFR expression...
Paper Details
Title
Piccolo mediates EGFR signaling and acts as a prognostic biomarker in esophageal squamous cell carcinoma
Published Date
Mar 6, 2017
Journal
Volume
36
Issue
27
Pages
3890 - 3902
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