Mitotic DNA Damage Response: At the Crossroads of Structural and Numerical Cancer Chromosome Instabilities

The cellular DDR signaling and downstream DNA repair pathways are active in the cell cycle during interphase. Their role in mitosis has long remained unknown. Emerging evidence suggests that the many proteins involved in DNA repair are also required for the progression of normal mitosis and faithful chromosome segregation. Mitotic cells can experience DNA damage either exogenously from therapy or endogenously due to unrepaired premitotic damage....