Tracking the fate and origin of clinically relevant adoptively transferred CD8 + T cells in vivo
Abstract
Adoptively transferred tumor-specific cells can mediate tumor regression in cancers refractory to conventional therapy. Autologous polyclonal tumor-specific cytotoxic T cells (CTL) generated from peripheral blood and infused into patients with metastatic melanoma show enhanced persistence, compared to equivalent numbers of more extensively expanded monoclonal CTL, and are associated with complete remissions (CR) in select patients. We applied...
Paper Details
Title
Tracking the fate and origin of clinically relevant adoptively transferred CD8 + T cells in vivo
Published Date
Feb 24, 2017
Journal
Volume
2
Issue
8
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Notes
History