Contact guidance requires spatial control of leading-edge protrusion
Abstract
In vivo, geometric cues from the extracellular matrix (ECM) are critical for the regulation of cell shape, adhesion, and migration. During contact guidance, the fibrillar architecture of the ECM promotes an elongated cell shape and migration along the fibrils. The subcellular mechanisms by which cells sense ECM geometry and translate it into changes in shape and migration direction are not understood. Here we pattern linear fibronectin features...
Paper Details
Title
Contact guidance requires spatial control of leading-edge protrusion
Published Date
Apr 15, 2017
Volume
28
Issue
8
Pages
1043 - 1053
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