IL-17 Signaling: The Yin and the Yang

IL-17-mediated inflammation is crucial for microbial clearance, while unrestrained IL-17 signaling can promote immunopathology. Signaling pathways activated by IL-17 lead to enhanced de novo gene transcription and also control of mRNA stability. To restrict bystander inflammation, IL-17 activates multiple negative regulators of signaling which target transcriptional activators as well as regulators of mRNA stability. IL-17 induces a core set of...