p53 protein accumulation predicts malignant progression in Barrett's metaplasia: a prospective study of 275 patients

Aims The purpose of this study was to determine prospectively whether p53 protein accumulation in biopsies of Barrett's metaplasia ( BM ) is a predictor of malignant progression, without relying on dysplasia grading. Methods and results Sections of formalin‐fixed paraffin‐embedded tissue from the initial biopsies of 275 patients with BM , who had no high‐grade dysplasia ( HGD ) or oesophageal adenocarcinoma ( EAC ), were stained for p53 by...