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doi.org/10.1016/j.cell.2017.02.006

Multivalent Small-Molecule Pan-RAS Inhibitors

..., Brent R. Stockwell
78
Cell64.50
Volume: 168, Issue: 5, Pages: 878 - 889.e29
Published: Feb 1, 2017
Abstract
Design of small molecules that disrupt protein-protein interactions, including the interaction of RAS proteins and their effectors, may provide chemical probes and therapeutic agents. We describe here the synthesis and testing of potential small-molecule pan-RAS ligands, which were designed to interact with adjacent sites on the surface of oncogenic KRAS. One compound, termed 3144, was found to bind to RAS proteins using microscale...
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Paper Details
Title
Multivalent Small-Molecule Pan-RAS Inhibitors
DOI
doi.org/10.1016/j.cell.2017.02.006
Published Date
Feb 1, 2017
Journal
Cell
Volume
168
Issue
5
Pages
878 - 889.e29
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