Review paper

Targeted protein degradation by PROTACs

Volume: 174, Pages: 138 - 144
Published: Jun 1, 2017
Targeted protein degradation using the PROTAC technology is emerging as a novel therapeutic method to address diseases driven by the aberrant expression of a disease-causing protein. PROTAC molecules are bifunctional small molecules that simultaneously bind a target protein and an E3-ubiquitin ligase, thus causing ubiquitination and degradation of the target protein by the proteasome. Like small molecules, PROTAC molecules possess good tissue...
Paper Details
Targeted protein degradation by PROTACs
Published Date
Jun 1, 2017
138 - 144
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