Paroxysmal Hypertension Induced by an Insulinoma.

Published on Feb 15, 2017in Internal Medicine1.005
· DOI :10.2169/INTERNALMEDICINE.56.7758
Ko Harada3
Estimated H-index: 3
(Okayama University),
Yoshihisa Hanayama6
Estimated H-index: 6
(Okayama University)
+ 4 AuthorsFumio Otsuka35
Estimated H-index: 35
(Okayama University)
Sources
Abstract
: Insulinoma is a rare, usually benign, pancreatic neuroendocrine tumor. The clinical features of an insulinoma are fasting hypoglycemia with neuroglycopenic symptoms including confusion and unusual behavior, while hypertension is usually not associated with the disease. We herein report a patient with insulinoma who manifested paroxysmal hypertension and neuroglycopenic symptoms. The possible etiology of hypertension induced by an insulinoma is catecholamine release in response to hypoglycemia, which may cause acute hypertension through activation of the sympatho-adrenal system. This case implies that sustained hyperinsulinemia due to insulinoma can be functionally linked to the induction of paroxysmal hypertension.
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