Heparin modified graphene oxide for pH-sensitive sustained release of doxorubicin hydrochloride

Volume: 75, Pages: 198 - 206
Published: Jun 1, 2017
Abstract
A novel nanocarrier of heparin (Hep) modified graphene oxide (GO) was fabricated via a linker (adipic dihydrazide) and used as a pH-sensitive drug delivery system for controlling the release of anticancer drug doxorubicin (DOX) for anti-tumor therapy. The finally obtained nanocarrier was GO-ADH-Hep with better stability, blood compatibility and biocompatibility confirmed by the hemolytic test and in vitro cytotoxicity study. Its safety issue was...
Paper Details
Title
Heparin modified graphene oxide for pH-sensitive sustained release of doxorubicin hydrochloride
Published Date
Jun 1, 2017
Volume
75
Pages
198 - 206
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