Discoidin Domain Receptor 1 Mediates Myosin-Dependent Collagen Contraction
Abstract
Discoidin domain receptor 1 (DDR1) is a tyrosine kinase collagen adhesion receptor that mediates cell migration through association with non-muscle myosin IIA (NMIIA). Because DDR1 is implicated in cancer fibrosis, we hypothesized that DDR1 interacts with NMIIA to enable collagen compaction by traction forces. Mechanical splinting of rat dermal wounds increased DDR1 expression and collagen alignment. In periodontal ligament of DDR1 knockout...
Paper Details
Title
Discoidin Domain Receptor 1 Mediates Myosin-Dependent Collagen Contraction
Published Date
Feb 14, 2017
Journal
Volume
18
Issue
7
Pages
1774 - 1790
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