Emerging role of liquid biopsy in detection of EGFR mutations from metastatic Lung Adenocarcinomas (mLA): concordance between analysis on tissue samples and in circulating free tumor DNA (cftDNA)

Background: The detection of EGFR mutations may predict sensitivity to EGFR-TKIs (Tyrosine Kinases Inhibitors) in mLA. This analysis is usually performed on tumor samples obtained by small biopsies or fine needle aspirations, that often provide insufficient tissue for molecular analysis. Moreover, a re-biopsy, that should be proposed to identify emerging mechanisms of resistance at disease progression, is not always feasible due to poor...