Trimethyl chitosan based conjugates for oral and intravenous delivery of paclitaxel.
Abstract
null null Paclitaxel (PTX) conjugated trimethyl chitosan (TMC-PTX) and folic acid (FA) modified TMC-PTX (FA-TMC-PTX) were developed as polymer-drug conjugates for oral and intravenous delivery of PTX. As amphiphilic conjugates, TMC-PTX and FA-TMC-PTX containing approximately 11 wt% PTX could self-assemble into spherical nanoparticles with average sizes of 170 and 187 nm, respectively. The conjugates presented a sustained release of PTX and the...
Paper Details
Title
Trimethyl chitosan based conjugates for oral and intravenous delivery of paclitaxel.
Published Date
Apr 15, 2017
Journal
Volume
53
Pages
355 - 366
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