ATP-Dependent Persister Formation in Escherichia coli
Volume: 8, Issue: 1
Published: Mar 8, 2017
Abstract
Persisters are dormant variants that form a subpopulation of cells tolerant to antibiotics. Persisters are largely responsible for the recalcitrance of chronic infections to therapy. In Escherichia coli , one widely accepted model of persister formation holds that stochastic accumulation of ppGpp causes activation of the Lon protease that degrades antitoxins; active toxins then inhibit translation, resulting in dormant, drug-tolerant persisters....
Paper Details
Title
ATP-Dependent Persister Formation in Escherichia coli
Published Date
Mar 8, 2017
Volume
8
Issue
1
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