Transcriptional repression of miR-200 family members by Nanog in colon cancer cells induces epithelial–mesenchymal transition (EMT)

Nanog is an important embryonic stem cell (ESC) gene that does not function as a classical oncogene, but needs to cooperate with other molecules to potentiate tumorigenic activity. The question addressed by the present study was whether a miRNA link exists between Nanog and epithelial–mesenchymal transition (EMT)-mesenchymal–epithelial transition (MET) plasticity. Here, we found that Nanog mRNA expression level was inversely correlated with...