Pharmacological approach to understanding the control of insulin secretion in human islets

Aims To understand better the control of insulin secretion by human β cells and to identify similarities to and differences from rodent models. Methods Dynamic insulin secretion was measured in perifused human islets treated with pharmacological agents of known modes of action. Results Glucokinase activation ( R o28‐1675) lowered the glucose threshold for stimulation of insulin secretion to 1 mmol/ L ( G1 ), augmented the response to G3‐G5 but...