Evaluation of the Surgical Device and Procedure for Extracellular Matrix–Scaffold–Supported Human iPSC–Derived Retinal Pigment Epithelium Cell Sheet Transplantation

Purpose: To develop a clinically applicable transplantation device and surgical procedure for extracellular matrix–scaffold–supported human-induced pluripotent stem cell–derived retinal pigment epithelium (hiPSC-RPE) cell sheet transplantation for clinical use. Methods: The developed surgical device consisted of a custom-designed hand piece and a cannula. The subretinal transplantation of hiPSC–RPE cell sheets was performed in 12 rabbits. The...