Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease

Aims Hyperphosphorylated tau neuronal cytoplasmic inclusions (ht‐ NCI ) are the best protein correlate of clinical decline in Alzheimer's disease ( AD ). Qualitative evidence identifies ht‐ NCI accumulating in the isodendritic core before the entorhinal cortex. Here, we used unbiased stereology to quantify ht‐ NCI burden in the locus coeruleus (LC) and dorsal raphe nucleus (DRN), aiming to characterize the impact of AD pathology in these nuclei...