Flavanols from the Camellia sinensis var. assamica and their hypoglycemic and hypolipidemic activities.

Published on May 1, 2017in Acta Pharmaceutica Sinica B7.097
· DOI :10.1016/J.APSB.2016.12.007
Xin Wang (Peking Union Medical College)
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Abstract
Abstract α -Glucosidase and lipase inhibitors play important roles in the treatment of hyperglycaemia and dyslipidemia. To identify novel naturally occurring inhibitors, a bioactivity-guided phytochemical research was performed on the pu-erh tea. One new flavanol, named (–)-epicatechin-3- O - (Z) -coumarate ( 1 ), and 16 known analogs ( 2 17 ) were isolated from the aqueous extract of the pu-erh tea. Their structures were determined by spectroscopic and chemical methods. Furthermore, the water extract of pu-erh tea and its fractions exhibited inhibitory activities against α -glucosidases and lipases in vitro ; compound 15 showed moderate inhibitory effect against sucrase with an IC 50 value of 32.5 μmol/L and significant inhibitory effect against maltase with an IC 50 value of 1.3 μmol/L. Compounds 8 , 10 , 11 and 15 displayed moderate activity against a lipase with IC 50 values of 16.0, 13.6, 19.8, and 13.3 μmol/L, respectively.
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