Chronic Granulomatous Disease

Pages: 485 - 493
Published: Jan 1, 2016
Abstract
Chronic granulomatous disease (CGD) is a rare inherited deficiency of the innate immune system caused by mutations of one of five genes encoding the subunits of the phagocyte NADPH oxidase (phox) complex. The phox deficiencies result in defective production of reactive oxygen species leading to impaired microbial killing and excessive inflammation. CGD is thus characterized by severe recurrent bacterial and fungal infections as well as...
Paper Details
Title
Chronic Granulomatous Disease
Published Date
Jan 1, 2016
Journal
Pages
485 - 493
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